AIM:To assess the vascularity of hepatocellular carcinoma (HCC)before and after transcatheter arterial chemoembolization(TACE) with the quantitative parameters obtained by firstpass perfusion weighted MR imaging (FP-MRI).METHODS:Seventeen consecutive patients with one tothree lesions in liver underwent FP-MRI before treatment.FP-MRI was also performed one,three,six,nine months,and one year after TACE.The baseline signal intensity (SO)of pre-TACE and one month after TACE was analyzed,thevascularity of HCC assessed by steepest slope of the signalintensity versus time curves (SS) was blindly correlatedwith their DSA feature and clinical outcome.RESULT:No significant difference was found on baselinesignal intensity (S0) between pre-TACE and one monthafter TACE (F=0.309,P=0.583),The SS (mean,32% persecond) of lesion one month after TACE was lower than thatof pre-TACE (mean,69% per second),but with no statisticalsignificance (F=3.067,P=0.092).When local recurrenceoccurred,the time intensity curves became steeper.Thevascularity of HCC before and after TACE graded by SS closelycorrelated with that by DSA (K=0.453,P<0.05).CONCLUSION:FP-MRI is a useful criterion for selectingeffective interventional treatment for patients with HCC intheir initial treatment and during follow up. AIM: To assess the vascularity of hepatocellular carcinoma (HCC) before and after transcatheter arterial chemoembolization (TACE) with the quantitative parameters obtained by firstpass perfusion weighted MR imaging (FP-MRI). METHODS: Seventeen consecutive patients with one tothree lesions in liver underwent FP-MRI before treatment. FP-MRI was also performed one, three, six, nine months, and one year after TACE. The baseline signal intensity (SO) of pre-TACE and one month after TACE was analyzed, the vascular of HCC by steepest slope of the signalintensity versus time curves (SS) was blindly correlated with their DSA feature and clinical outcome. RESULT: No significant difference was found on baselinesignal intensity (S0) between pre-TACE and one monthafter TACE (F = 0.309, 0.583), The SS (mean, 32% persecond) of lesion one month after TACE was lower than that of pre-TACE (mean, 69% per second), but with no statistical significance (F = 3.067, recurrenceoccurred, the time intensity curves became steeper. The vessel of HCC before and after TACE grafted by SS closelycorlated with that by DSA (K = 0.453, P <0.05) .CONCLUSION: FP-MRI is a useful criterion for selectingeffective interventional treatment for patients with HCC intheir initial treatment and during follow up