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百日咳杆菌、副百日咳杆菌和支气管败血性杆菌三者同属于博代氏杆菌属(Borde-tella),前两者为人类致病菌。到百日咳杆菌的培养特性、阳性的枸橼酸盐和尿素酶反应,不同于百日咳杆菌。两种细菌都具有不耐热的表面抗原,即凝集原,但百日咳杆菌可产生毒性很强的淋巴细胞增多促进因子(简称LPF),也称组胺过敏因子,副百日咳杆菌则不能产生此种毒素。用脂多糖抗原、不耐热的皮肤坏死毒素或菌毛血凝素(简称F-HA)均不能鉴别两种细菌。历来认为百日咳和副百日咳是分别由百日咳杆菌和
Bordetella pertussis, Bordetella pertussis, and Bordetella bronchiseptica belong to the genus Borde-tella, both of which are human pathogens. To B. pertussis culture characteristics, positive citrate and urease reactions, different from Bordetella pertussis. Both bacteria have thermolabile surface antigens, agglutinogens, but Bordetella pertussis produces highly toxic lymphocytosis promoting factor (LPF), also known as histamine hypersensitivity factor, and B. parapertussis does not produce this toxin. Two types of bacteria can not be identified with lipopolysaccharide antigen, heat-labile dermal necrotic toxin, or lenti-lectin (F-HA). Pertussis and vice pertussis have traditionally been considered by Bordetella pertussis