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我院针刺麻醉原理的研究是多学科协作进行的。从1975年开始,对内啡肽及其与针刺镇痛的关系进行了多方西的探索。我们在这里选载的一组关于针麻原理研究的论文和报导,就是这一课题研究的初步成果。主要包括。(1)从人及动物脑内提取到一种具有抗痛作用的吗啡样物质,它可能是一种新的内啡肽;(2)用纳洛酮等阿片受体阻断剂作为分析手段,以动物的行为反应、皮层诱发电活动、肢体血管容积及生化反应(脑内cAMP水平)等为指标,从受体的研究水平上来说明针刺镇痛和针刺抗内脏牵拉反应同内啡肽有关;(3)测定人脑脊液及动物脑内中央灰质淡流液中的内啡肽含量,观察到针刺镇痛时脑内内啡肽释放增加。从而,就在神经细胞突触前和突触后这样的水平上初步揭示了内啡肽系统同针刺镇痛的关系。 几年来,我们还同兄弟单位协作,围绕着脑内有关抗痛的结构、物质、功能系统等中心课题,通过大量动物实验和临床观察,证明脑内的尾核是针刺镇痛中起着重要作用的一个环节,尾核内的胆碱能神经细胞的活动参与针刺镇痛过程。此外,对尾核和脑内其他有关结构的形态同功能的联系以及尾核内一些已知递质在针刺镇痛中的作用等方面,都进行了一定的观察和研究,有关论文将另行选登。
Acupuncture anesthesia in our hospital research is multidisciplinary collaboration. Since 1975, a multi-lateral exploration of endorphins and their relationship with acupuncture analgesia has been conducted. The set of papers and reports we have selected here for the study of acupuncture anesthesia are the first results of this research. mainly include. (1) extracted from the human and animal brain to have a morphine-like substance with anti-pain effect, which may be a new endorphin; (2) naloxone and other opioid receptor blockers as a means of analysis , Animal behavioral response, cortical evoked electrical activity, limb vascular volume and biochemical reactions (intracerebral cAMP levels) as an indicator, from the receptor level of research to illustrate acupuncture analgesia and acupuncture anti-visceral traction reaction with the internal (3) determination of endorphin levels in the cerebrospinal fluid and animal gray matter in the central gray matter, and observed an increase in brain endorphin release during acupuncture analgesia. Thus, the relationship between the endorphin system and acupuncture analgesia is initially revealed at the level of presynaptic and post-synaptic nerve cells. Over the past few years, we also collaborate with our brothers and units around the brain center of the structural, material, functional systems and other anti-pain subjects, through a large number of animal experiments and clinical observation, that the caudate nucleus is acupuncture analgesia plays An important part of the role of cholinergic nerve cells in the caudate nucleus involved in the acupuncture analgesic process. In addition, the caudate nucleus and other related structures in the brain and the functional connection, as well as some of the known caudate nucleus neurotransmitter analgesia in acupuncture and so on, have carried out some observations and studies, the paper will be separate Selected election.