论文部分内容阅读
放射性核素用于示踪技术,以及灵敏度高(10~(-9)～10~(-15)克)、分析时需用的样品量及分析试剂量少、工作效率高、应用范围广等优点,在医学和药学研究中得到了日益广泛的应用。在这类方法中,有高效液相色谱(HPLC)法对放射性试剂、标记物及其衍生物进行分离、鉴定是比较理想的手段,所用的检测器除了紫外等常规检测器外,还须串联一个放射性检测器,用于检测HPLC洗出液中的放射性组分。目前国外已有少数几个厂商生产HPLC专用的放射性检测器,但价格昂贵,国内则尚无此类产品。我们利用放射性同位素实验室的现有设备,改装成一台HPLC放射性检测器,本文作简要的测试介绍。
Radionuclides for tracer technology, as well as high sensitivity (10 ~ (-9) ~ 10 ~ (-15) g), the sample required for analysis and analysis of small amount of reagents, high efficiency, wide range of applications Advantages, in the medical and pharmaceutical research has been more widely used. In such methods, high performance liquid chromatography (HPLC) method for radioactive reagents, markers and derivatives of separation, identification is an ideal means of using the detector in addition to UV and other conventional detectors, but also in series A radioactive detector for detecting radioactive components in HPLC eluate. At present, there are a few foreign manufacturers that produce HPLC-specific radioactive detectors, but they are expensive and there is no such product in China. We use existing equipment in the radioisotope laboratory to retrofit into an HPLC radioactive detector, which is briefly described in this article.