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目的:探讨人表皮生长因子受体(C-erbB-2)、血管内皮生长因子(VEGF-C)在乳腺癌组织中的表达及其对预后的临床意义。方法:收集我院2004年～2006年有完整存档蜡块资料的l58例乳腺癌蜡块,并采用SP法检测C-erbB-2、VEGF在乳腺癌组织中的表达,并且对二者的表达情况与疾病的病理生物学特点、患者的预后进行分析,以判断其对预后的意义。结果:C-erbB-2阳性表达59.5%,VEGF-C同样在乳腺癌组织中有高表达为70.9%,且与C-erbB-2的表达在统计学上具有正相关。C-erbB-2和VEGF表达均与患者肿瘤复发有密切关系,两者在肿瘤中的表达与肿瘤临床分期、淋巴结转移呈正相关。与雌激素受体(ER)、孕激素受体(PR)状态呈负相关。结论:C-erbB-2、VEGF-C在乳腺癌中均有高表达,且均与乳腺癌预后有关,可以作为乳腺癌预后的重要指标。
Objective: To investigate the expression of human epidermal growth factor receptor (C-erbB-2) and vascular endothelial growth factor (VEGF-C) in breast cancer and its clinical significance. Methods: A total of l58 cases of breast cancer paraffin blocks were collected from our hospital from 2004 to 2006, and the expressions of C-erbB-2 and VEGF in breast cancer tissues were detected by SP method. Pathological and biological characteristics of the disease and the prognosis of patients analyzed to determine the significance of its prognosis. Results: The positive expression of C-erbB-2 was 59.5%. The positive expression of VEGF-C in breast cancer was 70.9%, which was positively correlated with the expression of C-erbB-2. The expression of C-erbB-2 and VEGF are closely related to tumor recurrence in patients, and the expression of C-erbB-2 and VEGF is positively correlated with clinical stage and lymph node metastasis. And estrogen receptor (ER), progesterone receptor (PR) status was negatively correlated. Conclusion: The expression of C-erbB-2 and VEGF-C are both highly expressed in breast cancer, which are all related to the prognosis of breast cancer and may be used as an important prognostic indicator of breast cancer.