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在兔耳K~+透入测痛模型上,左旋四氢巴马汀(1-THP,8mg/kg,iv)的镇痛作用被双侧脑室注射多巴胺(DA)受体广谱激动剂DA或去水吗啡(Apo)以及选择性D_1受体激动剂SKF-38393减弱,被选择性D_2受体激动剂喹吡罗加强。另外,采用放射免疫分析和高效液相色谱——电化学检测法分别观察到1-THP镇痛时脑脊液中cAMP含量降低,及DA及其代谢产物DOPAC含量升高。提示1-THP镇痛与中枢D_1和D_2亚型DA受体有关,其中D_1受体的阻断导致其镇痛,而D_2受体的阻断不利于其镇痛。
The analgesic effect of L-tetrahydropalmatine (1-THP, 8 mg / kg, iv) was injected into the bilateral intracerebroventricular injection of dopamine (DA) receptor broad-spectrum agonist DA Or dehydro-morphine (Apo) and the selective D_1 receptor agonist SKF-38393 weakened, being potentiated by the selective D_2 receptor agonist quinopril. In addition, the levels of cAMP in cerebrospinal fluid and the content of DA and its metabolite DOPAC were observed respectively by radioimmunoassay and HPLC-electrochemical detection. It is suggested that the analgesia of 1-THP is related to the D_1 and D_2 subtypes of DA receptors in the central nervous system. The blocking of D_1 receptor leads to its analgesia, while the blocking of D_2 receptor is not conducive to its analgesia.