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目的:了解学龄前儿童HBV携带情况并分析其影响因素,为制定有效的干预措施提供可靠依据。方法:采用酶联免疫吸附法(ELISA)对14 203例入托儿童进行乙肝血清标志物HBsAg的检测。结果:2001～2007年扬中市入托儿童HB-sAg阳性率为0.47%,近几年来阳性率逐年下降,2007年与2001年、2002年比较差异有统计学意义(P<0.01,P<0.05)。结论:入托儿童HBV感染率较低,加强对婚龄人群的婚前医学检查,对高危儿童进行乙肝免疫球蛋白与乙肝疫苗联合接种,能有效预防HBV感染。
Objective: To understand the carrying status of HBV in preschool children and to analyze the influencing factors, so as to provide a reliable basis for making effective interventions. Methods: Serum HBsAg was detected in 14 203 infants with enzyme-linked immunosorbent assay (ELISA). Results: The positive rate of HBsAg in children admitted to Yangzhong from 2001 to 2007 was 0.47%. The positive rate of HBsAg in children dropped year by year in recent years. There was significant difference between 2007 and 2001 and 2002 (P <0.01, P <0.05) . Conclusions: The HBV infection rate of children in nursery is relatively low, which enhances the premarital medical examination for the marriage-age children and the combined immunization of hepatitis B immunoglobulin with hepatitis B vaccine for high-risk children, which can effectively prevent HBV infection.