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β-肾上腺能受体阻滞剂的降压效应,业已得到证实.在过去的15年中,世界各国对此类制剂之一,心得静开展了广泛研究.本文概述美国近5年来对心得静降压作用的研究资料.方法:300余名中、轻度高血压患者先进行3周安慰剂治疗,而后随机进入心得静组或对照组.对照药物包括安慰剂(65例)、心得安(52例)、双氢氯噻嗪(简称双克,38例)、α-甲基多巴(62例)和氯噻酮(14例).本试验按3种方式进行:(1)舒张压(卧位,下同)>95毫米汞柱者应用固定剂量(分别为15、30、60毫克/日)的心得静(固定剂量组).(2)舒张压≥105毫米汞柱者应用不定剂量的心得静治
The antihypertensive effect of β-adrenergic receptor blockers has been confirmed, and in the past 15 years, many countries in the world have made a great deal of study about this type of preparations.This article summarizes the experience of the United States in the past five years Methods: More than 300 moderate and mild hypertensive patients were treated with placebo for 3 weeks and then randomized to receive either intravenous or placebo (control group, placebo, n = 65), propranolol 52 cases), hydrochlorothiazide (38 cases), α-methyldopa (62 cases) and chlorthalidone (14 cases) .This experiment was conducted in three ways: (1) diastolic blood pressure , The same below)> 95 mm Hg were applied fixed dose (respectively 15,30,60 mg / day) of the static (fixed dose group) (2) diastolic blood pressure ≥ 105 mm Hg application of undetermined dose experience Static rule