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对８２例呼吸道合胞病毒性毛细支气管炎患儿用放射免疫法测定血浆内皮素－１水平，并进行１２～２８个月随访观察。８２例中３０例（３６．６％）发展为婴幼儿哮喘。发展为婴幼儿哮喘组患儿血浆内皮素－１水平明显高于未发展为婴幼儿哮喘组（Ｐ＜０．００１）。结果表明，呼吸道合胞病毒性毛细支气管炎患儿血浆内皮素－１水平高者以后发展为婴幼儿哮喘的可能性较大。推测对呼吸道合胞病毒性毛细支气管炎患儿采用内皮素桔抗剂或封闭内皮素受体的治疗措施，可能有预防婴幼儿哮喘的作用。同时测定了患儿全血中肿瘤坏死因子，以了解其与内皮素的关系。
Plasma endothelin-1 levels were measured by radioimmunoassay in 82 children with respiratory syncytial virus bronchiolitis and were followed up for 12 to 28 months. In 82 cases, 30 cases (36.6%) developed asthma in infants and children. Plasma endothelin-1 levels in infants and young children with asthma were significantly higher than those who did not develop asthma in infants (P <0.001). The results show that children with respiratory syncytial virus bronchiolitis plasma endothelin-1 levels after the development of infant asthma is more likely. Presumably for children with respiratory syncytial virus bronchiolitis endothelin antagonist or closed endothelin receptor therapy may have the role of prevention of infant asthma. At the same time, the determination of tumor necrosis factor in children with whole blood to understand its relationship with endothelin.