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目的探讨血清Delta样配体4(DLL4)、血管内皮生长因子(VEGF)的表达水平与食管癌的相关性。方法将53例食管癌患者作为试验组,20例健康体检者作为对照组,采用免疫组化法检测DLL4与VEGF水平。结果食管癌组中DLL4的阳性表达率为81.13%,VEGF的阳性表达率为64.15%;对照组中DLL4、VEGF均无表达,2组DLL4、VEGF的阳性表达率比较差异均有统计学意义(P<0.05)。DLL4与VEGF在食管癌血清中表达与肿瘤TNM分期、淋巴结转移、组织学分化、远处转移及浸润深度密切相关(P<0.05);与患者的年龄、性别、肿瘤大小无关(P>0.05)。VEGF表达率在DLL4表达为阳性的患者中明显高于DLL4表达为阴性的患者,DLL4与VEGF的表达水平呈现正相关(r=0.343,P<0.05)。结论 DLL4与VEGF在食管癌患者中的阳性表达率高于健康患者,DLL4在食管癌中的表达水平升高与VEGF有关,两者与食管癌的分期和预后有密切的关系。
Objective To investigate the relationship between the expression of serum Delta-like ligand 4 (DLL4) and vascular endothelial growth factor (VEGF) and esophageal cancer. Methods 53 cases of esophageal cancer patients as the experimental group, 20 healthy subjects as control group, immunohistochemical detection of DLL4 and VEGF levels. Results The positive expression rate of DLL4 in esophageal cancer group was 81.13% and the positive rate of VEGF was 64.15%. There was no expression of DLL4 and VEGF in the control group, and there were significant differences in the expression rates of DLL4 and VEGF between the two groups P <0.05). The expression of DLL4 and VEGF in esophageal cancer serum was closely related to TNM staging, lymph node metastasis, histological differentiation, distant metastasis and depth of invasion (P <0.05), but not related to age, sex and tumor size (P> 0.05) . The positive rate of VEGF expression in patients with positive expression of DLL4 was significantly higher than that in patients with negative expression of DLL4. There was a positive correlation between the expression of DLL4 and VEGF (r = 0.343, P <0.05). Conclusion The positive expression rate of DLL4 and VEGF in esophageal cancer patients is higher than that in healthy patients. The increased expression of DLL4 in esophageal cancer is related to VEGF, which is closely related to the staging and prognosis of esophageal cancer.