论文部分内容阅读
他汀类降脂药通过抑制3-羟基-甲基戊二酰辅酶A(HMG-COA)还原酶而起到降脂作用。主要包括洛伐他汀、辛伐他汀、普伐他汀、阿托伐他汀等多种药物,被广泛应用于血脂异常的相关性疾病,特别是动脉粥样硬化,高血压和冠心病等心血管疾病。近年来发现他汀类药物的作用除降脂以外还有多种作用,包括提高一氧化氮生物利用度、修复受损内皮、抗炎、抗氧化、促新生血管生成、抗血小板聚集、稳定动脉粥样硬化(AS)斑块、抑制心肌肥厚,抗心律失常[1]等。本文
Statins lipid-lowering agents act as lipid-lowering agents by inhibiting 3-hydroxy-methylglutaryl coenzyme A (HMG-COA) reductase. Mainly lovastatin, simvastatin, pravastatin, atorvastatin and other drugs, is widely used in dyslipidemia-related diseases, especially atherosclerosis, hypertension and coronary heart disease and other cardiovascular diseases . In recent years, the role of statins has been found to play a variety of roles besides lipid lowering, including increasing bioavailability of nitric oxide, repairing damaged endothelium, anti-inflammatory, antioxidant, angiogenic, anti-platelet aggregation, Like sclerosis (AS) plaque, inhibition of cardiac hypertrophy, anti-arrhythmia [1] and so on. This article