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目的:建立复方水杨酸糊、氧化锌糊和复方松馏油糊3种医院糊剂微生物限度检查方法。方法:按《中国药典》2010年版二部微生物限度检查法中对细菌、霉菌及酵母菌计数方法和控制菌检查法进行验证。结果:复方水杨酸糊和氧化锌糊细菌、霉菌及酵母菌计数和控制菌检查均采用培养基稀释法;复方松馏油糊细菌、霉菌及酵母菌计数检查和铜绿假单胞菌菌检查采用培养基稀释法,金黄色葡萄球菌检查采用薄膜过滤法。结论:确立了3种医院糊剂微生物限度检查方法可有效控制其质量。
OBJECTIVE: To establish a method for checking the limits of microbial paste in three kinds of hospitals based on compound salicylic acid paste, zinc oxide paste and compound saponin paste. Methods: According to the “Chinese Pharmacopoeia” 2010 edition of the two microbial limit test method for bacteria, mold and yeast count method and control bacteria test to verify. Results: The counts and control bacteria of the compound salicylic acid paste and zinc oxide paste bacteria, the mold and the yeast were all examined by the culture medium dilution method; the compound truffle paste paste, mold and yeast count test and the Pseudomonas aeruginosa test Using culture medium dilution method, Staphylococcus aureus examination using membrane filtration method. Conclusion: It is established that three kinds of hospital paste microbial limit test methods can effectively control the quality.