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[目的]探讨成纤维生长因子受体-1(FGFR-1)及细胞周期蛋白D1(CyclinD1)在胃癌组织中的表达及其临床意义。[方法]应用免疫组织化学S-P法检测70例胃癌(24例腺癌,21例黏液腺癌,25例印戒细胞癌)组织中FGFR-1、CyclinD1蛋白水平的表达。[结果 ]胃癌中FGFR-1蛋白的阳性率为61.4%(43/70),明显高于癌旁组织的37.5%(15/40)(P<0.05);FGFR-1在浸润深度超过肌层2/3病例中阳性率为79.5%(31/39),浸润深度未达到肌层2/3病例中阳性率为38.7%(12/31)(P<0.05);伴区域淋巴结转移病例阳性率为69.4%(34/49),无区域淋巴结转移病例阳性率为42.9%(9/21)(P<0.05)。胃癌中CyclinD1蛋白的阳性率为64.3%(45/70),明显高于癌旁组织的25.0%(10/40)(P<0.05);CyclinD1在浸润深度超过肌层2/3病例中阳性率为79.5%(31/39),浸润深度未达到肌层2/3病例中阳性率为45.2%(14/31)(P<0.05);伴区域淋巴结转移病例阳性率为73.5%(36/49),无区域淋巴结转移病例阳性率为42.9%(9/21)(P<0.05)。[结论 ]FGFR-1在胃癌中表达上调,与胃癌的浸润和转移密切相关,其可能通过上调CyclinD1的表达而发挥作用。
[Objective] To investigate the expression of fibroblast growth factor receptor-1 (FGFR-1) and cyclinD1 in gastric carcinoma and its clinical significance. [Method] The expression of FGFR-1 and CyclinD1 protein in 70 cases of gastric carcinoma (24 cases of adenocarcinoma, 21 cases of mucinous adenocarcinoma and 25 cases of signet-ring cell carcinoma) were detected by immunohistochemical S-P method. [Results] The positive rate of FGFR-1 protein in gastric cancer was 61.4% (43/70), which was significantly higher than that in adjacent non-cancerous tissues (37.5%, 15/40) (P <0.05) The positive rate was 79.5% (31/39) in 2/3 cases, and the positive rate was 38.7% (12/31) (P <0.05) in 2/3 of the cases whose invasion depth did not reach the muscular layer. The positive rate of regional lymph node metastasis (69.4%, 34/49). The positive rate of non-regional lymph node metastasis was 42.9% (9/21) (P <0.05). The positive rate of CyclinD1 protein in gastric cancer was 64.3% (45/70), which was significantly higher than that in adjacent tissues (25.0%, 10/40) (P <0.05). The positive rate of CyclinD1 was higher than 2/3 (33/39), and the positive rate was 45.2% (14/31) (P <0.05), and the positive rate was 73.5% (36/49) in patients with regional lymph node metastasis ). The positive rate of non-regional lymph node metastasis was 42.9% (9/21) (P <0.05). [Conclusion] The up-regulation of FGFR-1 in gastric cancer is closely related to the infiltration and metastasis of gastric cancer, which may play a role by up-regulating the expression of CyclinD1.