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本文对180例肝病患者血清透明质酸(Hyalur-onic Acid,HA)含量进行检测,并探讨HA在肝病不同时期的变化及临床意义。 材料和方法 一、对象:本组肝病患者180例(男120,女60),年龄20～75岁,平均49.2岁。均为我院住院及门诊患者。其中乙型肝炎病毒携带者80例,肝硬化代偿期患者60例,肝硬化失代偿期患者40例,诊断均按1990年(上海)第6届全国病毒性肝炎会议修订标准进行确诊。对照组80例(男54,女26),年龄25～71岁,平均45.2岁,均为我院门诊体检合格的健康人。 二、方法:HA RIA kit由上海放射免疫分析技术研究所提供,操作按说明书。取空腹静脉血2ml,分离血清置-20℃待测,每周定期测定,仪器为西安262厂生产的γ免疫计数仪。 结果 乙型肝炎病毒携带者与肝硬化组血清HA含量见表1。 讨论 HA是一种大分子氨基多糖,由间质细胞合成,在体内参与基质的构成,经淋巴入血,大部分迅速被肝内皮细胞摄取降解。当肝实质细胞在遭到病毒、
In this paper, 180 cases of liver disease in patients with serum hyaluronic acid (Hyalur-onic Acid, HA) content detection, and explore the HA in different stages of liver disease changes and clinical significance. Materials and methods First, the object: 180 cases of liver disease patients (male 120, female 60), aged 20 to 75 years, mean 49.2 years. All of our hospital and outpatient patients. Including hepatitis B virus carriers in 80 cases, 60 patients with decompensated liver cirrhosis and 40 patients with decompensated liver cirrhosis were diagnosed according to the 1990 (Shanghai) 6th National Conference on the revision of viral hepatitis to confirm the diagnosis. The control group of 80 cases (54 males and 26 females), aged 25 to 71 years, mean 45.2 years old, were outpatient medical examination in our hospital qualified healthy people. Second, the method: HA RIA kit by the Shanghai Institute of radioimmunoassay, according to the instructions. Take fasting venous blood 2ml, isolated serum -20 ℃ to be measured, measured regularly every week, the instrument for the Xi’an 262 plant production of γ immune counter. Results Hepatitis B virus carriers and cirrhosis serum HA levels in Table 1. Discussion HA is a macromolecular amino polysaccharide, synthesized by interstitial cells, in the body involved in the formation of the matrix, the lymphatic into the blood, most of the rapid degradation of liver endothelial cells uptake. When the liver parenchymal cells in the virus,