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目的 探讨恶性肿瘤特异性生长因子 (TSGF)在小儿恶性实体瘤诊断中的临床意义。方法 对正常组(1 68例 )、良性肿瘤组 (32例 )、恶性肿瘤组 (51例 )及感染组 (31例 )血清中TSGF的浓度分别进行检测。结果 恶性肿瘤组病儿血清中TSGF浓度与正常组比较明显升高 (P <0 .0 1 ) ,良性肿瘤组与正常组比较无差异性。感染组病儿在治疗前血清中TSGF浓度与正常组比较也有升高 (P <0 .0 1 ) ,但治疗后 2周血清中TSGF浓度会下降至正常范围内。以60U/ml为正常参考值 ,则诊断灵敏度为 88%、特异性为 89%。结论 TSGF对小儿恶性实体瘤有诊断意义 ,具有很高的特异性、敏感性和广谱性。炎症对TSGF有很强的干扰性 ,当使用TSGF作为恶性肿瘤诊断时 ,应排除炎症因素
Objective To investigate the clinical significance of the diagnosis of malignant solid tumors in children with malignant tumor-specific growth factor (TSGF). Methods Serum concentrations of TSGF in normal group (18 68 cases), benign tumor group (32 cases), malignant tumor group (51 cases) and infected group (31 cases) were detected respectively. Results Serum levels of TSGF in the malignant tumor group were significantly higher than those in the normal group (P <0.01). There was no difference between the benign tumor group and the normal group. Serum levels of TSGF in patients with infection were also significantly higher than those in the normal control group (P <0.01). However, the levels of TSGF in serum decreased to within the normal range after 2 weeks of treatment. With 60 U / ml as the normal reference, the diagnostic sensitivity was 88% and the specificity was 89%. Conclusions TSGF is of diagnostic significance for malignant solid tumors in children with high specificity, sensitivity and broad spectrum. Inflammation of TSGF has a strong interference, when the use of TSGF as a malignant tumor diagnosis, should be ruled out inflammatory factors