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目的：探索β１整合素表达与儿童髓母细胞瘤各病理类型和临床预后的关系。材料和方法：单克隆抗体对５７例手术切除的髓母细胞瘤的福尔马林固定石蜡切片行免疫组织化学染色，结合临床随访，使用Ｃｏｘ回归和Ｐｅａｒｓｏｎ相关统计分析。结果：多数髓母细胞瘤表达β１整合素。结论：典型性、纤维性、多形性三种病理类型的髓母细胞瘤β１整合素表达无明显差别；β１整合素表达与髓母细胞瘤临床预后存在高度负相关关系，提示β１整合素表达愈高，其临床预后愈差。
Objective: To explore the relationship between the expression of β1 integrin and the pathological types and prognosis of childhood medulloblastoma. MATERIALS AND METHODS Monoclonal antibodies were immunohistochemically stained for formalin-fixed paraffin sections of 57 surgically resected medulloblastoma using Cox regression and Pearson correlation with clinical follow-up. RESULTS: Most medulloblastomas expressed β1 integrin. CONCLUSION: There is no significant difference in the expression of β1 integrin among the three pathological types of medulloblastoma, which are typical, fibrous and pleomorphic. The expression of β1 integrin is highly negatively correlated with the clinical prognosis of medulloblastoma, suggesting the expression of β1 integrin The higher the worse the clinical prognosis.