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目的评价小剂量沙利度胺联合治疗MDS的疗效。方法低中危病例15例,低危组给予小剂量沙利度胺加司坦唑醇、促红细胞生成素,中危组给予小剂量沙利度胺加全反式维甲酸、小剂量阿糖胞苷化疗,3个月后评价疗效。结果低危组有效率达77.8%。中危组有效率33.3%。在改善贫血方面,对低危的MDS红系效果改善明显,对巨核系效果不佳。结论联合小剂量沙利度胺治疗MDS对改善贫血效果显著。
Objective To evaluate the efficacy of low-dose thalidomide combined with MDS. Methods 15 cases of low and medium risk cases were given low-dose thalidomide plus stanozolol and erythropoietin. The medium-risk group was given low-dose thalidomide plus all-trans retinoic acid, low dose of sugar Cytidine chemotherapy, evaluation of efficacy after 3 months. Results The low-risk group was 77.8%. Medium risk group effective rate of 33.3%. In improving anemia, red blood cells at low risk significantly improved the effect of the Department of MDR, the effect is not good. Conclusion The combination of low-dose thalidomide and MDS can significantly improve anemia.