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目的观察丙型肝炎患者肝功能异常,在治疗前后网织红细胞参数变化,探讨其在肝损伤患者中临床意义。方法应用Beckman-Coulter公司的LH750型全自动血液分析仪,观察40例健康成人、37例丙肝患者肝功能异常治疗前后和25例丙肝患者肝功能无异常的网织红细胞参数变化。结果与健康成人比较,肝功能异常患者的RET%.IRF明显升高(P<0.05)。肝功能异常治疗后,丙肝患者肝功能无异常,和健康成人各项指标差异无统计学意义。结论通过网织红细胞参数的变化,对早期丙型肝炎患者肝损伤的诊断有一定临床意义。
Objective To observe the abnormal liver function in patients with hepatitis C and to study the changes of reticulocyte parameters before and after treatment and to explore its clinical significance in liver injury patients. Methods The Beckman-Coulter LH750 automatic hematology analyzer was used to observe the changes of reticulocyte parameters before and after the treatment of liver dysfunction in 40 healthy adults and 37 patients with hepatitis C and in 25 patients with hepatitis C without abnormal liver function. Results Compared with healthy adults, RET% .IRF in patients with abnormal liver function was significantly higher (P <0.05). After the treatment of abnormal liver function, there was no abnormal liver function in hepatitis C patients, and there was no significant difference between healthy adults and other indicators. Conclusion The changes of reticulocyte parameters have some clinical significance in the diagnosis of liver injury in patients with early hepatitis C.