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目的 :探讨骨骼肌原发的间变性大细胞淋巴瘤的临床病理特征和免疫表型。方法 :采用常规制片和免疫组化 (S P)法检测 1例 (14岁 )骨骼肌原发的间变性大细胞淋巴瘤。结果 :肿瘤细胞CD30、ALK 1、CD4 5RO和CD4 5阳性 ;而CD2 0、EMA、S 10 0蛋白、desmin和CD6 8阴性。结论 :本例为间变性淋巴瘤激酶 (ALK)阳性的间变性大细胞淋巴瘤。骨骼肌原发的间变性大细胞淋巴瘤非常少见 ,诊断时应先排除其它肿瘤和其它部位淋巴瘤累及骨骼肌。
Objective: To investigate the clinicopathological characteristics and immunophenotype of primary anaplastic large cell lymphoma in skeletal muscle. Methods: One case (14 years old) of primary anaplastic large cell lymphoma of skeletal muscle was detected by routine method and immunohistochemistry (S P) method. Results: The tumor cells were positive for CD30, ALK 1, CD4 5RO and CD4 5, while CD20, EMA, S 10 0, desmin and CD68 were negative. Conclusion: This is an anaplastic lymphoma kinase (ALK) -positive anaplastic large cell lymphoma. Skeletal muscle primary anaplastic large cell lymphoma is very rare, the diagnosis should be ruled out other tumors and other parts of the lymphoma involving skeletal muscle.