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目的通过检测患者血清铁调素(Hepcidin)和血清可溶性转铁蛋白受体(s TfR)的水平,探讨2种指标在儿童缺铁性贫血(IDA)中的关系及应用价值。方法选取3岁~7岁学龄前儿童IDA患者30例、健康对照组30例为研究对象。应用ELISA法检测Hepcidin,生化分析仪检测s TfR。结果 IDA患儿血清Hepcidin水平明显下降,s TfR浓度显著升高,与对照组相比差异有统计学意义(P<0.01)。根据受试者工作特征(ROC)曲线,Hepcidin诊断儿童IDA曲线下的面积为0.91,敏感度为0.87,特异度为0.90;s TfR诊断儿童IDA曲线下的面积为0.93,敏感度为0.93,特异度为0.83。两指标联合诊断儿童IDA曲线下的面积为0.97,敏感度为0.97,特异度为0.87。Hepcidin与s TfR呈负相关(r=-0.725,P<0.01)。结论血清Hepcidin和s TfR联合诊断,有助于提高儿童IDA的临床诊断价值。
Objective To investigate the relationship between the serum levels of soluble hepcidin (s TfR) and serum soluble transferrin receptor (s TfR) in children with iron deficiency anemia (IDA) and its clinical value. Methods 30 IDA patients from 3 years old to 7 years old and 30 healthy controls were selected as study subjects. Hepcidin was detected by ELISA and s TfR by biochemical analyzer. Results Serum levels of Hepcidin in IDA children were significantly decreased, and s TfR levels were significantly increased (P <0.01). According to the receiver operating characteristic (ROC) curve, the area under IDA curve of Hepcidin in diagnosis of children was 0.91, the sensitivity was 0.87 and the specificity was 0.90. The area under IDT curve of s TfR diagnosis was 0.93 and the sensitivity was 0.93 The degree is 0.83. The area under the IDA curve for the combined diagnosis of the two indicators was 0.97, with a sensitivity of 0.97 and a specificity of 0.87. Hepcidin was negatively correlated with s TfR (r = -0.725, P <0.01). Conclusions Combined diagnosis of serum Hepcidin and s TfR may help to improve the clinical diagnostic value of IDA in children.