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为探讨尿 AAP测定在紫癜性肾炎中的临床意义 ,本文应用速率法和放射免疫法测定 32例紫癜性肾炎患儿尿AAP和 m Alb。经观察尿 AAP与 m Alb呈正相关 (γ=0 .712 ) ,2 0例对照组尿 AAP活性为 8.84± 2 .6 1u/ g.Cr,患儿组尿 AAP活性为 16 .6± 5 .94u/ g.Cr,两者有非常显著性差异 (P<0 .0 0 1)。 14例患儿治疗前与缓解后尿 AAP分别为 19.40± 5 .6 8,11.0 8±4.72 u/ g.Cr,差异非常显著 (P<0 .0 0 1)。4例尿检阴性紫癜性肾炎患儿与对照组相比有显著性差异 (P<0 .0 5 )。资料显示 :尿 AAP活性可较特异的反应肾脏早期损伤情况 ,是紫癜性肾炎诊断及疗效判定的较好指标
In order to investigate the clinical significance of urine AAP in purpura nephritis, the urinary AAP and m Alb in 32 children with purpura nephritis were measured by the rate method and radioimmunoassay. The observed urine AAP and m Alb showed a positive correlation (γ = 0.72). The urinary AAP activity of 20 controls was 8.84 ± 2.61u / g.Cr, and the urinary AAP activity in the children was 16.6 ± 5. 94u / g.Cr, the two have very significant difference (P <0. The difference of urinary AAP before and after remission in the 14 children was 19.40 ± 5.68, 11.0 8 ± 4.72 u / g.Cr, respectively (P <0.01). There was a significant difference between the 4 children with urinary tract-negative purpura nephritis and the control group (P <0.05). Data show that: urinary AAP activity can be more specific response to early kidney damage, is a good indicator of diagnosis and curative effect of purpura nephritis