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目的：探讨类 Ｐ３ Ｌ 在痴呆动物模型确立中的作用。方法：用外科手术切断大鼠左侧穹窿－ 海马伞（ Ｆ Ｆ） 的方法建立 Ａｌｚｈｅｉｍｅｒ 病（ Ａ Ｄ） 大鼠模型，于建模前后对其进行迷宫检查和类 Ｐ３ 潜伏期（ 类 Ｐ３ Ｌ） 测定。结果： Ａ Ｄ 大鼠类 Ｐ３ Ｌ 较对照组有显著延长，并与迷宫试验指标错误反应次数（ Ｅ Ｎ） 增多及总反应时间（ Ｔ Ｒ Ｔ） 延长呈正相关。结论：类 Ｐ３ Ｌ 为痴呆动物模型的确立提供了一个较为客观而可行的电生理指标
Objective: To investigate the role of P3L in the establishment of animal model of dementia. METHODS: Alzheimer’s disease (AD) rat models were established by surgical excision of the left fornix-fornix (F F) in rats. Maladjustment and P3-like latency (P3L) measurements were performed before and after modeling . Results: The P3 L level of AD rats was significantly longer than that of control rats, and positively correlated with the increase of error response times (E N) and prolongation of total reaction time (T R T) in maze test. CONCLUSION: The class P3 L provides a more objective and feasible electrophysiological indicator for the establishment of a dementia animal model