[Objective] The paper was to explore chemical control of Ceratovacuna lanigera Zehntner with multi-rotor unmanned aerial vehicle. [Method] According to the outbreak characteristics of C. lanigera,multi-rotor unmanned aerial vehicle was applied for flying control test. Referred to the spraying characteristics of multi-rotor unmanned aerial vehicle,two kinds of microcapsule pesticides,ALV-1501 and ALV-1502,and two kinds of spraying additives,SPA-01 and SPA-02,were designed to control C. lanigera. [Result] The control effect of ALV-1501 at the dose of 2. 25 L/hm~2 was 60. 02% at 1 d post administration and 54. 14%at 5 d post administration; the control effects of ALV-1502 at the dose of 2. 1 L/hm2 were 76. 35% and 81. 35% at 1 and 5 d post administration,respectively.Compared to individual pesticide,the control effects of ALV-1501 were improved 1. 42-1. 47 times and 1. 16-1. 14 times by adding 0. 6 L/hm~2 SPA-01 and SPA-02 in pesticide liquid,respectively. The control effects of ALV-1502 were improved 1. 23-1. 25 times and 1. 15-1. 16 times by adding 0. 6 L/hm2 SPA-01 and SPA-02,respectively. The control effects against C. lanigera at three flying speeds of 3,5 and 8 m/s were 99. 72%-99. 97%,81. 6%-99. 81% and63. 52%-68. 77%,respectively. [Conclusion]The results will provide a reference for application of multi-rotor unmanned aerial vehicle in prevention and control of C. lanigera in sugarcane field. [Objective] The paper was to explore chemical control of Ceratovacuna lanigera Zehntner with multi-rotor unmanned aerial vehicle. [Method] According to the outbreak characteristics of C. lanigera, multi-rotor unmanned aerial vehicle was applied for flying control test. Referred to the spraying characteristics of multi-rotor unmanned aerial vehicle, two kinds of microcapsule pesticides, ALV-1501 and ALV-1502, and two kinds of spraying additives, SPA- 01 and SPA- 02, were designed to control C. lanigera. ] The control effect of ALV-1501 at the dose of 2. 25 L / hm ~ 2 was 60. 02% at 1 d post administration and 54. 14% at 5 d post administration; the control effects of ALV-1502 at the dose of 2. 1 L / hm2 were 76. 35% and 81. 35% at 1 and 5 d post administration, respectively. Compared to individual pesticide, the control effects of ALV-1501 were improved 1. 42-1. 47 times and 1. 16-1. 14 times by adding 0. 6 L / hm ~ 2 SPA-01 and SPA-02 in pesticide liquid, respectively. The control effects of ALV-1502 were improved 1. 23-1. 25 times and 1. 15-1. 16 times by adding 0. 6 L / hm2 SPA-01 and SPA-02, respectively. The control effects against C. lanigera at three flying speeds of 3 , 5 and 8 m / s were 99. 72% -99. 97%, 81. 6% -99. 81% and 63. 52% -68. 77%, respectively. [Conclusion] The results will provide a reference for application of multi-rotor unmanned aerial vehicle in prevention and control of C. lanigera in sugarcane field.