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用DXS28、J-Bir、DXS164和DXS84探针对一个BMD和两个DMD家系进行RFLP连锁分析,在DMD家系中,JBir/BamH Ⅰ和pERT87-1Msp Ⅰ杂交组合均能提供信息,表明该家系中先证者之妹是DMD致病基因携带者。在一个BMD家系中发现有pERT87-1的缺失,并进行了缺失分析。
RFLP linkage analysis was performed on one BMD and two DMD pedigrees with DXS28, J-Bir, DXS164 and DXS84 probes. In the DMD pedigree, the combination of JBir / BamH I and pERT87-1 Msp I both provided information that The proband’s sister is a DMD pathogenic carrier. Deletion of pERT87-1 was found in one BMD pedigree and deletion analysis was performed.