论文部分内容阅读
作者在实验室观察了二甲基肼(DMH)的诱发小鼠结肠癌作用,系通过给予小鼠半乳糖苷果糖和(或)硫酸钠,酸化其结肠内容物,然后再注射DMH致癌。结果发现,这些小鼠结肠癌的发生明显低于对照组(仅注射DMH者)。方法:将4～6周的小鼠分为四个不同的饮食组,每组25只。第一组给予一般性饲养,以下各组在维持小鼠体重的基础上给予添加物,第二组添加半乳糖苷果糖,第三组添加硫酸钠,第四组给予上述两种添加物。药物的浓度与用于人类时相似:每20g药物中含半乳糖苷果糖糖浆1.5ml或硫酸钠50mg。饲养4周后,在连续16周内,每周皮下注射
The authors observed the effect of dimethyl hydrazine (DMH) in inducing colon cancer in mice by acidifying its colon contents by administering mouse galactosyl fructose and / or sodium sulfate and then re-injecting DMH to cause cancer. The results showed that these mice colon cancer was significantly lower than the control group (only DMH injection). Methods: Four to six weeks old mice were divided into four different diet groups, 25 in each. The first group was given general feeding. The following groups were given supplements on the basis of maintaining body weight of mice, the second group added galactoside fructose, the third group added sodium sulfate, the fourth group administered the above two additives. The drug concentration is similar to that used in humans: 1.5ml of galactosyl fructose syrup, or 50mg sodium sulphate, per 20g of drug. After 4 weeks of feeding, they were injected subcutaneously weekly for 16 consecutive weeks