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目的:研究溃结安康汤对溃疡性结肠炎大鼠SOD影响及其作用机制。方法:健康Wistar大鼠,随机分为空白对照组、模型组、补脾益肠丸组、SASP组、溃结安康汤组。TNBS/乙醇法建立溃疡性结肠炎大鼠模型。分组灌胃治疗后,检测溃结大鼠结肠组织SOD活性。结果:结果显示:模型组与正常组比较,SOD活性降低,具有统计学意义(P<0.05);补脾益肠丸组、SASP组、溃结安康汤组与模型组比较,SOD活性增强,具有统计学意义(P<0.05);溃结安康汤组与补脾益肠丸组、SASP组比较,SOD活性明显增强,具有统计学意义(P<0.05)。结论:溃结安康汤可以增加溃疡性结肠炎大鼠模型中结肠组织SOD活性。
Objective: To investigate the effect and mechanism of Kuijieankang decoction on SOD in rats with ulcerative colitis. Methods: Healthy Wistar rats were randomly divided into blank control group, model group, Bupiyishang pill group, SASP group and Kuijieankang Decoction group. Establishment of rat model of ulcerative colitis by TNBS / ethanol method. Grouping gavage treatment, detection of ulcerative colonic tissue SOD activity. Results: The SOD activity of the model group was significantly lower than that of the normal group (P <0.05). Compared with the model group, the activity of SOD was increased in the Bupi Yichang pill group, the SASP group and the Kuijieankang Decoction group, (P <0.05). Compared with Bupi Yichang pill group and SASP group, the activity of SOD in Kui Jie Ankang Decoction group was significantly increased (P <0.05). Conclusion: Kuijieankang Decoction can increase the activity of SOD in colon tissue of ulcerative colitis rats.