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目的调查吕梁地区21种人乳头状瘤病毒基因型的检测分析。方法收集568例女性宫颈病变患者宫颈分泌物中的脱落细胞,应用人乳头状瘤病毒导流杂交快速基因分型技术检测21种人乳头状瘤病毒亚型,包括13种高危亚型(16,18,31,33,35,39,45,51,52,56,58,59和68型)、5种低危亚型(6,11,42,43和44型)和3种中国人群常见亚型(53,66和CP8304型);分析21种基因型的流行病学特征。结果人乳头状瘤病毒感染率41.9%,单一感染率58.4%,混合性感染率39.9%。21种基因型中,高危型以16,53型为主,其次是52,58型,低危型以6,11型为主;人乳头状瘤病毒16型的感染率居首位。结论本地区21种人乳头状瘤病毒基因型的检测分析资料对人乳头状瘤病毒疫苗研究、应用及其感染的防治有重要意义。
Objective To investigate the genotypes of 21 human papilloma viruses in Luliang region. Methods A total of 21 human papilloma virus subtypes were detected by rapid genotyping by flow-through hybridization of human papillomavirus (HPV) in cervical secretions from 568 women with cervical lesions, including 13 high-risk subtypes (16, 33, 35, 39, 45, 51, 52, 56, 58, 59 and 68), five low risk subtypes (6, 11, 42, 43 and 44), and three Chinese Subtypes (types 53, 66 and CP8304); Epidemiological characteristics of 21 genotypes were analyzed. Results Human papilloma virus infection rate was 41.9%, single infection rate was 58.4% and mixed infection rate was 39.9%. Of the 21 genotypes, high-risk type was mainly 16,53 type, followed by 52,58 type and low-risk type was type 6,11 type. Human papillomavirus type 16 infection rate ranked first. Conclusion The detection and analysis of 21 human papillomavirus genotypes in this region are of great significance to the research, application and prevention and cure of human papillomavirus vaccine.