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本研究从体内和体外两方面探讨了川芎嗪对肺气肿的防治作用。体外试验发现川芎嗪对弹性蛋白酶(简称:弹性酶)有明显的抑制作用,治疗剂量可取代血清防治肺气肿。体内实验是以弹性酶肺气肿动物模型观察血清弹性酶抑制力(SEIC)正常的血清和川芎嗪对弹性酶在肺内的积聚及其活性的影响;在光镜和电镜下对肺组织形态加以测量,用体视学方法分析。结果表明实验防治组未出现模型组的病理变化,与生理盐水对照组相近。用气溶胶法制成豚鼠弹性酶肺气肿模型并用川芎嗪防治有效,为探讨人类肺气肿发生机制和防治提供了实验依据。
This study explored the preventive and therapeutic effects of tetramethylpyrazine on emphysema in vivo and in vitro. In vitro studies have found that tetramethylpyrazine has a significant inhibitory effect on elastase (abbreviation: elastase), and the therapeutic dose can replace the serum to prevent emphysema. The in vivo experiment was conducted to observe the effects of elastase emphysema animal model and serum with normal serum elastase inhibitory force (SEIC) on the accumulation and activity of elastase in the lung; the morphology of lung tissue under light microscope and electron microscope Measured and analyzed stereologically. The results showed that the experimental group did not show pathological changes in the model group, similar to the saline control group. The guinea pig elastase emphysema model was made by aerosol method and was effectively controlled by ligustrazine. It provided experimental basis for exploring the mechanism and prevention of human emphysema.