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目的:探讨脑内毛细血管的生长发育与形态结构和功能的关系.方法:用透射电镜对35只不同发育时期小鼠血脑屏障建立过程中的超微结构及血管密度进行了分析.结果:胚胎第15、18天血管密度较低,出生后第一天血管密度增长明显,第7天下降,以后随年龄增长血管密度逐渐增加.内皮细胞由厚变薄,胞质减少,细胞间宽间隙减少,紧密连接范围增大;血管平均截面积逐渐减少,管腔的体密度增大,内皮细胞核的体密度呈波浪形变化.周细胞数量逐渐减少,基膜逐渐完整增厚;各组血管密度之差与血管壁厚度之差呈正相关;星形胶质细胞胞突末端膨大,包绕着血管的范围渐增大.结论:研究为血脑屏障在各种生理或病理状态下的功能变化提供形态学依据.
OBJECTIVE: To investigate the relationship between the morphological structure and function of capillaries in the brain.METHODS: The ultrastructure and blood vessel density of the blood brain barrier in 35 different developmental stages were analyzed by transmission electron microscopy.Results: The vascular density was lower on the 15th and 18th day of embryos, the density of blood vessel increased obviously on the first day after birth and decreased on the 7th day, and the density of blood vessel increased gradually with the increase of age later.Endothelial cells changed from thick to thin, cytoplasm, The number of pericytes decreased gradually, the area of tight junction increased, the mean cross-sectional area of blood vessels decreased gradually, the density of lumen increased, the body density of endothelial nuclei changed wavy shape, the number of pericytes decreased, And the difference of vascular wall thickness was positively correlated.The end of the astroglioma dilated and surrounded the blood vessels.Conclusion: This study provides a theoretical basis for the functional changes of the blood-brain barrier under various physiological or pathological conditions Morphological basis.