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目的探讨中国北方地区汉族人生长转化因子(TGF)基因型别的多态性与多发性骨髓瘤(MM)的相关性。方法对21例MM患者采用顺序特异性引物-聚合酶链反应(PCR-SSP)方法,检测TGF基因型别的多态性变化,并与35名健康献血者对照组进行对比分析。结果 MM组TGF(H)等位基因频率(38.09%)显著高于正常对照组(11.43%),P<0.05;提示该等位基因频率增高与MM的发病相关;而TGF其它等位基因频率在MM组和对照组中无明显差异。结论我国北方地区汉族人TGF(H)基因与MM的易感性相关联。
Objective To investigate the association of polymorphism of growth factor (TGF) genotypes with multiple myeloma (MM) in Han Chinese in northern China. Methods Twenty-one patients with MM were tested for the polymorphism of TGF genotypes by PCR-SSP with 35 healthy blood donors. Results The frequency of TGF (H) allele in MM group (38.09%) was significantly higher than that in normal control group (11.43%), P <0.05. It suggested that the increased frequency of this allele was associated with the onset of MM. The frequency of other alleles There was no significant difference between the MM group and the control group. Conclusion The Han Chinese TGF (H) gene in Northern China is associated with the susceptibility to MM.