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乙酰唑胺是一种碳酸酐酶抑制剂,作用于肾小管通常为自身限制性重碳酸盐利尿。尽管此药广泛应用(先用于利尿,近来又用于治疗青光眼和幼年型癫痫病),但据我们所知,因服用乙酰唑胺引起严重代谢性酸中毒而停药者已有两例报道。本文报道为第三例,同时讨论与并发糖尿病性肾炎的可能联系, 病例报告:女性,24岁,因严重过度换气而于1977年8月急诊入院。患者4岁患糖
Acetazolamide is a carbonic anhydrase inhibitor that acts on the tubular usually self-limiting bicarbonate diuretic. Although this medicine is widely used (first for diuresis and more recently for the treatment of glaucoma and juvenile epilepsy), to the best of our knowledge, there have been two reports of discontinuation due to severe metabolic acidosis caused by acetazolamide . This article reports the third case and discusses the possible association with diabetic nephritis. Case report: Female, 24 years old, admitted to emergency department in August 1977 due to severe hyperventilation. Patient 4 years old suffering from sugar