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目的指导临床医生和患者合理使用非甾体类抗炎药,尽量避免冠心病的发生与发展。方法对近年来关于非甾体类抗炎药与冠心病的一些回顾性研究进行分析、归纳、总结。结果非选择性非甾体类抗炎药如双氯酚酯、布洛芬有增加心血管事件的危险;相反,阿司匹林、萘普生及美罗昔康使心绞痛复发率,心肌梗死和死亡的发生率,需要冠状动脉血管重建的百分率均明显减少。而特异性COX-2抑制剂具有液体潴留、恶化高血压、增加心血管事件的发生与发展。结论非甾体类抗炎药尤其是特异性COX-2抑制剂具有促进冠心病的发生与发展,但仍需临床研究进一步证实。
Objective To guide clinicians and patients in rational use of non-steroidal anti-inflammatory drugs, to avoid the occurrence and development of coronary heart disease. Methods In recent years, some retrospective studies on non-steroidal anti-inflammatory drugs and coronary heart disease were analyzed, summarized and summarized. Results Non-selective NSAIDs such as diclofenac and ibuprofen increased the risk of cardiovascular events; conversely, aspirin, naproxen, and meloxicam increased the incidence of angina pectoris, myocardial infarction, and death , Requiring a significant reduction in the percentage of coronary revascularization. Specific COX-2 inhibitors have fluid retention, worsen hypertension and increase the occurrence and development of cardiovascular events. Conclusion Non-steroidal anti-inflammatory drugs, especially specific COX-2 inhibitors, can promote the occurrence and development of coronary heart disease, but they still need clinical studies to further confirm.