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目的:探讨同型半胱氨酸(Hcy)、胱抑素C(Cys-C)在经皮冠状动脉介入治疗(PCI)术后对比剂肾病(CIN)发生的预测价值。方法:分析300例行PCI患者的临床资料,按CIN分为CIN组与非CIN组,比较两组间的基线资料。用多因素Logistic回归分析评估Hcy、Cys-C与CIN的相关性。结果:300例发生CIN 45例(15%),CIN组Hcy、Cys-C比非CIN组明显升高。Hcy、Cys-C、肾功能不全、糖尿病、高龄(>75岁)、糖尿病、肾小球滤过率减低、大剂量造影剂、心力衰竭均是CIN的独立危险因素。结论:Hcy、Cys-C可成为PCI后患者发生CIN简捷、可靠的指标。
Objective: To investigate the predictive value of homocysteine (Hcy) and cystatin C (Cys-C) in the development of contrast-induced nephropathy (CIN) after percutaneous coronary intervention (PCI). Methods: The clinical data of 300 patients undergoing PCI were analyzed. CIN group and non-CIN group were divided by CIN. Baseline data were compared between the two groups. Multivariate logistic regression analysis was used to assess the association of Hcy, Cys-C with CIN. Results: CIN was found in 45 cases (15%) in 300 cases. Hcy and Cys-C in CIN group were significantly higher than those in non-CIN group. Hcy, Cys-C, renal insufficiency, diabetes mellitus, elderly (> 75 years), diabetes mellitus, decreased glomerular filtration rate, high dose contrast media, and heart failure are all independent risk factors for CIN. Conclusion: Hcy and Cys-C can be used as simple and reliable CIN markers in patients with CIN.