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目的分析氟康唑联合克霉唑对复发性假丝酵母菌性阴道炎患者血清C反应蛋白(CRP)、降钙素原(PCT)及白细胞计数(WBC)水平的影响及疗效评价。方法选择2016年1-6月潜江市妇幼保健院妇科收治的复发性假丝酵母菌性阴道炎患者156例随机分为观察组和对照组各78例,观察组患者采用氟康唑、克霉唑联合用药,对照组患者采用克霉唑单独治疗,比较两组患者血清CRP、PCT及WBC水平变化及疗效。结果两组患者治疗1周后,血清CRP、PCT及WBC水平均出现降低,观察组下降更为显著,差异有统计学意义(P<0.05);治疗1周后两组患者近期治愈率差异无统计学意义(P>0.05),治疗3个月后两组患者治愈率差异有统计学意义(P<0.05),观察组治愈率较高。结论氟康唑联合克霉唑治疗复发性假丝酵母菌性阴道炎有良好的效果,能有效抑制假丝酵母菌性阴道炎的复发,值得在临床推广应用。
Objective To analyze the effect of fluconazole combined with clotrimazole on serum C-reactive protein (CRP), procalcitonin (PCT) and white blood cell count (WBC) in patients with recurrent Candida vaginitis and evaluate the therapeutic effect. Methods 156 cases of recurrent Candida vaginitis admitted to gynecology department of Qianjiang MCH hospital from January to June in 2016 were randomly divided into observation group and control group, 78 cases each. Patients in observation group were treated with fluconazole, Combination therapy of clotrimazole and control group was given clotrimazole alone. The changes of CRP, PCT, PCT and WBC levels in two groups were compared. Results After two weeks of treatment, serum CRP, PCT and WBC levels decreased in both groups, and the difference between the two groups was statistically significant (P <0.05). After one week of treatment, there was no difference in the recent cure rates Statistical significance (P> 0.05), after 3 months of treatment, the difference between the two groups was statistically significant (P <0.05). The cure rate in observation group was higher. Conclusion Fluconazole combined with clotrimazole treatment of recurrent Candida vaginitis has a good effect, can effectively inhibit the recurrence of Candida vaginitis, worthy of clinical application.