细胞凋亡是受到包括基因在内多因素调控的主动性细胞死亡过程,是在多种内外部信号刺激下细胞内部机制被激活进而导致细胞自我毁灭的过程。在癫痫过程中,NMDA受体激活、细胞内Ca2+超载以及基因表达的异常等各种因素相互作用,导致神经元凋亡,本文综述了癫痫过程中导致神经元凋亡发生的多种因素。 Apoptosis is an active cell death process regulated by multiple factors, including genes. It is a process in which the internal mechanism of cells is activated under a variety of internal and external signal stimuli and leads to cell self-destruction. In the process of epilepsy, NMDA receptor activation, intracellular Ca2 + overload and gene expression abnormalities and other factors interact, leading to neuronal apoptosis, the paper summarizes a variety of factors leading to neuronal apoptosis during epilepsy.