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目的:观察两种不同治则的中药清胆胶囊和养肝利胆颗粒对豚鼠胆色素结石形成过程中炎症环节的影响。方法:应用雄性豚鼠建立胆色素结石模型,分别观察清胆胶囊和养肝利胆颗粒对该模型成石率、胆囊容积、胆汁中黏蛋白浓度及C反应蛋白(CRP)浓度等指标的影响。结果:清胆胶囊组与养肝利胆颗粒组成石率均显著降低(P<0.01),胆囊容积明显减小(P<0.05);胆汁中黏蛋白及CRP浓度明显降低(P<0.05),两种中药制剂对黏蛋白及CRP的影响无统计学意义。结论:清胆胶囊与养肝利胆颗粒对胆色素结石有良好的防治作用,而且二者在干预胆色素结石病炎症反应环节上的作用效果和机制基本相似。
OBJECTIVE: To observe the effects of two different traditional Chinese medicines, Qingdan capsules and Yanggan Lidan Granules, on inflammatory aspects of guinea pig gallstone formation. METHODS: Male guinea pigs were used to establish a gallstone pigment model. The effects of Qingdan Capsule and Yanggan Lidan Granules on the stone formation rate, gallbladder volume, mucin concentration in bile, and C-reactive protein (CRP) concentration were observed. Results: The composition rate of Qingdan capsule group and Yanggan Lidan granules were significantly decreased (P<0.01), gallbladder volume was significantly reduced (P<0.05), and mucin and CRP concentrations in bile were significantly decreased (P<0.05). There was no statistically significant difference in the effects of two traditional Chinese medicine preparations on mucin and CRP. Conclusion: Qingdan Capsules and Yanggan Lidan Granules have good preventive and therapeutic effects on gallstone pigment stones, and the effect and mechanism of the two are similar in the intervention of inflammatory reaction of gallstone pigment stone disease.