论文部分内容阅读
铅暴露的情况存在于许多企业中,如电子厂、蓄电池厂、冶炼厂、电子垃圾回收厂等。在相同的铅暴露水平上,不同的人群有不同的生物学效应。这在很大程度上取决于人群的遗传易感性。通过铅暴露场所的流行病学调查,运用血尿铅检测、外周血彗星实验、微核实验等方法可以研究铅暴露人群的健康效应与遗传易感性之间的关系,该文介绍了铅遗传易感性基因[δ-氨基-γ-酮戊酸脱水酶(δ-ALAD)基因、维生素D受体基因(VDR)、血色素沉着病基因(HFE)等]与铅暴露的关系,以及铅暴露对发育相关基因(Cbfα1、Brn-3α、Oct-2等)的影响,提出应对铅暴露人群加强易感基因的筛查,保护易感人群健康。
Lead exposure exists in many enterprises, such as electronics factory, battery factory, smelter, e-waste recycling plant. Different populations have different biological effects at the same level of lead exposure. This depends very much on the genetic susceptibility of the population. Through the epidemiological investigation of lead exposure sites, using the hematuria lead test, peripheral blood comet assay, micronucleus test methods can study the relationship between the health effects of lead exposure and genetic susceptibility, this article describes the lead genetic susceptibility The relationship between lead exposure and the development of genes [delta-aminolevulinic acid dehydratase (delta-ALAD) gene, vitamin D receptor gene (VDR), hemochromatosis gene (HFE) (Cbfα1, Brn-3α, Oct-2, etc.), we propose to strengthen the screening of susceptible genes to lead exposure and protect the health of susceptible people.