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5-羟色胺转运体(5-HTT)在神经精神心理正常功能的维持及疾病的发生和发展中起重要作用。5-HTT的表达能力减低或消失的小鼠(称为:5-HTT敲除小鼠)表现出许多行为的改变,例如:焦虑类似行为增多、对应激更加敏感和攻击性行为减少。这些行为的改变有的与携带5-HTTLPR短等位基因的人很相似。因此5-HTT敲除小鼠被作为研究5-HTTLPR多态性导致情感性精神障碍发病机制的动物模型。本文主要就5-HTT敲除小鼠的5-HT浓度和代谢、下丘脑-垂体-肾上腺皮质轴以及对其他神经递质转运体影响的分子和细胞改变进行综述。
Serotonin transporter (5-HTT) plays an important role in the maintenance of normal function of neuropsychiatric and the occurrence and development of disease. Mice with reduced or absent expression of 5-HTT (referred to as: 5-HTT knockout mice) showed many behavioral changes, such as increased anxiety-like behaviors, increased sensitivity to stress, and reduced aggressive behavior. Some of these behavioral changes are very similar to those carrying the short 5-HTTLPR allele. Therefore, 5-HTT knockout mice were used as animal models for studying the pathogenesis of 5-HTTLPR polymorphisms leading to affective disorders. This review focuses on the molecular and cellular changes of 5-HT concentration and metabolism, hypothalamic-pituitary-adrenocortical axis and the effects on other neurotransmitter transporters in 5-HTT knockout mice.