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目的:探讨晚期血吸虫病巨脾型患者肝脏胶原与血清肝纤维化指标之间的关系。方法:采用免疫组化LSAB法,计算机图像分析和放射免疫法测定晚期血吸虫病巨脾型患者肝脏Ⅰ、Ⅲ、Ⅳ型胶原量燕计算Ⅰ/Ⅲ型胶原比值,同步检测血清PCⅢ、HA和CⅣ量。结果:血清HA与肝脏Ⅰ型胶原量,PCⅢ和CⅣ与Ⅰ/Ⅲ型胶原比值显著正相关。结论:血清PCⅢ和CⅣ能反映肝纤维化程度,血清肝纤维化指标与肝脏胶原病理检查对诊断肝纤维化具有互补性。
Objective: To investigate the relationship between liver collagen and serum liver fibrosis in patients with advanced splenosis of splenomegaly. Methods: The ratios of type Ⅰ / Ⅲ collagen were calculated by immunohistochemical LSAB method, computer image analysis and radioimmunoassay in the detection of liver type Ⅰ, Ⅲ and Ⅳ collagen in patients with advanced splenosis of splenomegaly. Simultaneous detection of serum PC Ⅲ, HA and C Ⅳ the amount. Results: There was a significant positive correlation between serum HA and liver type Ⅰ collagen, PC Ⅲ and C Ⅳ and type Ⅰ / Ⅲ collagen. Conclusion: The serum levels of PCⅢ and CⅣ can reflect the degree of liver fibrosis. The indexes of serum liver fibrosis and liver collagen pathology are complementary to the diagnosis of hepatic fibrosis.