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本院1966年～1989年共收治小儿卵黄囊瘤37例,经血清甲胎蛋白(AFP)测定,光镜确定诊断又通过10例电镜观察,8例AFP免疫组化观察,文献复习,本文支持Teilum提出该瘤来源于卵黄囊瘤背壁的全能性生殖细胞的组织发生观点;1.胚胎卵黄囊有合成AFP能力,本文意儿血清AFP明显升高,免疫酶标可作AFP定位。2.超微结构观察:肿瘤形态与妊娠7周卵黄囊相似,电镜下可见到上皮性及间叶性成份相当于胚外内胚层及胚外中胚层成份。且讨论了该瘤的命名与畸胎瘤关系和免疫组化的应用
The hospital from 1966 to 1989 were treated 37 cases of children with yolk sac tumor, serum alpha-fetoprotein (AFP) determination, light microscope confirmed by 10 cases of electron microscopy, 8 cases of AFP immunohistochemistry, literature review, this article supports Teilum proposed that the tumor originated from the histological appearance of pluripotent germ cells in the dorsal wall of yolk sac tumor.1. The embryo yolk sac has the ability of synthesizing AFP. Serum AFP in this paper is significantly elevated, and the immunoenzyme label can be used for AFP localization. 2. Ultrastructural observation: The morphology of the tumor was similar to that of the yolk sac 7 weeks of gestation. The epithelial and mesenchymal components were found to be equivalent to the extraembryonic endoderm and the extraembryonic mesoderm under electron microscopy. The relationship between naming and teratoma and the application of immunohistochemistry were discussed