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本文报道用不同剂量~(60)Coγ线照射离体血液后淋巴细胞染色体畸变的结果。染色体断片、双着、着环、易位、四倍体细胞和总畸变率均随照射剂量增加而升高。用电子计算机处理数据表明,四倍体细胞与剂量呈线性回归(R=0.966492),其余均为幂函数关系(R≥0.990373)。在观察到的1103个双着丝点体中,有194个无伴随的断片,占总数17.59％。比较不同供血者的血样,双核淋巴细胞率、四倍体细胞率和D/D+F比率越高者,其总畸变细胞率就越低,这种情况往往发生在淋巴细胞转化率低的供血者。资料表明人体的免疫反应程度可影响到畸变细胞的数目。
This article reports the results of chromosomal aberrations of lymphocytes after ex vivo blood irradiation with different dose of ~ (60) Coγ ray. Chromosome fragmentation, double-bearing, ring, translocation, tetraploid cells and total aberration rates increased with increasing radiation dose. Data processing with a computerized computer showed a linear regression of the tetraploid cells to the dose (R = 0.966492) and the rest were power functions (R> 0.90373). Of the 1103 dicentric spots observed, 194 had no accompanying fragments, accounting for 17.59% of the total. Comparing blood samples from different blood donors, the higher the ratio of binuclear lymphocytes, tetraploidy and D / D + F, the lower the rate of total aberrant cells, which often occurs in patients with low lymphocyte transformation rates By. Data show that the degree of human immune response can affect the number of abnormal cells.