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局部食管鳞癌的非手术标准疗法为放疗加化疗,虽然联合治疗较单独放疗可以提高局控率及生存率,但局部失败率仍达45％,为提高疗效,作者采用了新的方案和剂量,进行了多中心二期前瞻性非同期对照研究(ECOG PE-289RTOG 90-12)。 1991年3月～1994年5月共治疗45例,其中38例可评价,男27例,女11例,平均年龄61岁(38～77)岁,均为AJC TNM T_(1～4)N_(0～1)M_0颈段、中段、下段食管鳞癌。患者先接受三周期化疗:5-FU1g/m~2/24h,d_(1～5),顺铂100mg/m~2,d_1,每月一周
The non-surgical standard therapy for local esophageal squamous cell carcinoma is radiotherapy and chemotherapy. Although combined therapy can increase the local control rate and survival rate compared with radiotherapy alone, the local failure rate still reaches 45%. In order to improve the curative effect, the authors adopted a new regimen and dose. A multicenter, two-stage, prospective, asynchrony-controlled study (ECOG PE-289RTOG 90-12) was conducted. From March 1991 to May 1994, a total of 45 cases were treated, of which 38 cases could be evaluated. There were 27 males and 11 females. The average age was 61 years (38-77) years old. All of them were AJC TNM T_(1~4)N_. (0 ~ 1) M_0 cervical, middle, lower esophageal squamous cell carcinoma. The patient received three cycles of chemotherapy: 5-FU1g/m~2/24h, d_(1~5), cisplatin 100mg/m~2, d_1, one week per month