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以4-羟基-2,2,4,4-四甲基哌啶氮氧自由基为引发剂,通过ε-己内酯(ε-CL)的开环聚合反应,合成氮氧稳定自由基为末端基的聚己内酯(PCL-T);在其“介调”下,进行乙烯基吡咯烷酮(NVP)的氮氧稳定自由基聚合(NMP),得到结构规整聚己内酯和聚乙烯吡咯烷酮两亲性的嵌段共聚物(PCL-b-PNVP).通过核磁共振氢谱(1H NMR)、红外光谱(FTIR)、电子自旋共振(ESR)和凝胶渗透色谱(GPC)对聚合物的结构进行了表征.利用荧光光谱、动态光散射(DLS)、透射电镜(TEM)等手段分析共聚物自组装行为.结果表明,在聚己内酯大分子氮氧自由基“介调”下,合成了结构规整的PCL-b-PNVP共聚物,该共聚物在水中可自组装成粒径100 nm左右的核壳结构球形胶束;且共聚物表现出良好的生物相容性,可作为疏水性药物的载体材料.
Using 4-hydroxy-2,2,4,4-tetramethylpiperidine nitroxide as initiator, the ring-opening polymerization of ε-caprolactone (ε-CL) Terminated polycaprolactone (PCL-T); under its “mediation”, a nitroxyl free radical polymerization (NMP) of vinylpyrrolidone (NVP) was performed to give structurally regular polycaprolactone and poly Vinylpyrrolidone amphiphilic block copolymer (PCL-b-PNVP) was synthesized and characterized by 1H NMR, FTIR, ESR and GPC The structure of the polymer was characterized by means of fluorescence spectroscopy, dynamic light scattering (DLS), transmission electron microscopy (TEM) and other means of self-assembly behavior of the copolymer.The results showed that polycaprolactone macromolecular nitroxide In this paper, a structured PCL-b-PNVP copolymer was synthesized. The copolymer was self-assembled into spherical core-shell micelles with a diameter of about 100 nm in water. The copolymer showed good biocompatibility Sex, can be used as a hydrophobic drug carrier material.