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利福平又称利福霉素SV或甲哌利福霉素,是半合成的抗结核病抗生素,具有广谱抗菌作用,临床上多与其他抗结核药物合并使用,疗效显著,对结核分枝杆菌、革兰氏阳性菌和部分革兰氏阴性菌都有抑菌或杀菌作用,主要用于耐药结核植菌和耐药金葡菌的感染,亦用于抗麻风病治疗。粗品利福平母液中含较高含量的利福平,本文以溶酶萃取法回收母液中的利福平,选取合理、有效的溶剂确定最佳的回收工艺路线,以提高产品的收率,并解决环保问题。
Rifampicin, also known as rifamycin SV or meperidine rifamycin, is a semi-synthetic anti-tuberculosis antibiotics, with broad-spectrum antibacterial effect, the clinical combination with other anti-TB drugs, the effect is significant, the tuberculosis branch Bacillus, Gram-positive bacteria and some Gram-negative bacteria have bacteriostatic or bactericidal effect, mainly for drug-resistant TB bacilli and drug-resistant Staphylococcus aureus infection, also for anti-leprosy treatment. Crude rifampicin mother liquor containing a higher content of rifampicin, this article by lysozyme extraction method to recover the mother liquor rifampicin, choose a reasonable and effective solvent to determine the best recovery process route to improve product yield, And solve environmental problems.