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目的:对比国产环丙沙星与进口环丙沙星治疗下呼吸道感染的疗效。方法:下呼吸道感染患者96例,按使用国产环丙沙星(商品名悉复欢,广州产)还是进口环丙沙星(商品名西普乐,德国产)治疗分为国产组和进口组,各48例。比较2组的疗效、细菌清除率、未清除菌株组成、体外药敏试验的敏感菌百分率及不良反应。结果:国产组和进口组的治疗总有效率、细菌清除率、体外药敏试验的敏感菌百分率分别为88%和90%、88%和88%、92%(37/40)和95%(40/42),比较差异均无统计学意义(P>0.05);国产组与进口组未清除菌株比较、不良反应比较,差异均无统计学意义(P>0.05)。结论:国产环丙沙星的治疗总有效率、细菌清除率、未清除菌株组成、体外药敏试验的敏感菌百分率及不良反应与进口环丙沙星基本一致,具有较好的疗效,不良反应轻,用于治疗下呼吸道感染安全、有效,且药物来源充足,值得临床推广使用。
Objective: To compare the efficacy of domestic ciprofloxacin and imported ciprofloxacin in the treatment of lower respiratory tract infection. Methods: 96 patients with lower respiratory tract infection were divided into domestic group and imported group according to the treatment with domestic ciprofloxacin (trade name Sifu Huan, Guangzhou) or imported ciprofloxacin (Ciprofloxacin, German) , Each 48 cases. The curative effect of the two groups were compared, the bacterial clearance rate, the composition of the unselected strains, the percentage of sensitive bacteria in vitro susceptibility test and the adverse reactions were compared. Results: The total effective rate of treatment, bacterial clearance rate and sensitive susceptibility test in domestic and imported groups were 88% and 90%, 88% and 88%, 92% (37/40) and 95% 40/42). There was no significant difference between the two groups (P> 0.05). There was no significant difference in adverse reactions between domestic and imported groups (P> 0.05). Conclusion: The total effective rate of ciprofloxacin treatment, bacterial clearance rate, the composition of the strains not yet cleared, the percentage of susceptible strains in vitro susceptibility testing and adverse reactions are basically the same as imported ciprofloxacin, with good efficacy, adverse reactions Light, for the treatment of lower respiratory tract infection is safe and effective, and adequate source of drugs, it is worth promoting the use of the clinic.