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目的研究瑞舒伐他汀钙强化降脂治疗颈动脉粥样硬化的疗效与安全性。方法选择我院2015年5月至2016年2月颈动脉粥样硬化患者70例随机分两组。常规组给予瑞舒伐他汀钙每晚10mg治疗6个月,强化组给予瑞舒伐他汀钙每晚20mg治疗6个月。比较两组患者颈动脉粥样硬化治疗总有效率;不良反应发生率;施行治疗前和施行治疗后患者颈动脉内膜-中膜厚度、颈动脉斑块面积的差异。结果强化组患者颈动脉粥样硬化治疗总有效率高于常规组,P<0.05;两组不良反应发生率无显著差异,P>0.05;施行治疗前两组颈动脉内膜-中膜厚度、颈动脉斑块面积比较无显著差异,P>0.05;施行治疗后强化组颈动脉内膜-中膜厚度、颈动脉斑块面积改善幅度更大,P<0.05。结论瑞舒伐他汀钙强化降脂治疗颈动脉粥样硬化的疗效确切,可有效缩小颈动脉斑块面积,降低颈动脉内膜-中膜厚度,无明显副作用,安全性高,值得推广。
Objective To study the efficacy and safety of rosuvastatin calcium-fortified lipid-lowering therapy in the treatment of carotid atherosclerosis. Methods From May 2015 to February 2016, 70 patients with carotid atherosclerosis were randomly divided into two groups. The conventional group received 10 mg of rosuvastatin per night for 6 months, and the intensive group received 20 mg of rosuvastatin per night for 6 months. The total effective rate of carotid atherosclerosis and the incidence of adverse reactions were compared between the two groups. The differences of carotid intima-media thickness and carotid plaque area before and after the treatment were observed. Results The total effective rate of carotid atherosclerosis in the intensive group was higher than that in the conventional group (P <0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P> 0.05). The carotid intima-media thickness, There was no significant difference in carotid plaque area between the two groups (P> 0.05). After treatment, carotid intima-media thickness and carotid plaque area in the intensive group were improved more significantly (P <0.05). Conclusion Rosuvastatin calcium-lowering lipid-lowering therapy for carotid atherosclerosis is effective and can effectively reduce carotid plaque area, reduce carotid artery intima-media thickness, no obvious side effects, high safety, and worth promoting.