论文部分内容阅读
透明细胞乳头状肾细胞癌(ccpRCC)和肾血管平滑肌腺肌瘤样肿瘤(RAT)在形态学上与透明细胞肾细胞癌(ccRCC)和乳头状RCC(pRCC)有许多相似之处。目前争论的问题是,能否依据其形态学、免疫表型和分子学特征定义为独立的肾细胞癌实体。本研究目的在于调查涉及缺氧诱导因子通路和VHL基因突变中的特异性肾免疫组化标记物,来阐明与ccpRCC和RAT的关联。作者在28例ccpRCC和9例RAT样本中研
Clear cell papillary renal cell carcinoma (ccpRCC) and renal vascular smooth muscle adenomatous neoplasia (RAT) have many similarities in morphology to clear cell renal cell carcinoma (ccRCC) and papillary RCC (pRCC). The question for the moment is whether it can be defined as an independent renal cell carcinoma entity based on its morphological, immunophenotypic and molecular characteristics. The aim of this study was to investigate specific kidney immunohistochemical markers involved in hypoxia-inducible factor pathway and VHL gene mutations to elucidate the association with ccpRCC and RAT. The authors studied in 28 ccpRCC and 9 RAT samples