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目的:分析上海嘉定社区人群中外周动脉病(PAD)的患病率及其与体质量指数(BMI)的关系。方法:采用整群抽样的方法,选取上海嘉定区40岁以上的社区居民5 435名。所有受试者均接受口服75 g葡萄糖耐量试验(OGTT)、血脂的测定以及踝肱指数(ABI)的检测。将ABI<0.9作为PAD的诊断标准。采用Logistic回归法分析BMI与PAD的相关性。结果:在5 435名受试者中,PAD的患病率为7.10%,其中男性为8.35%,明显高于女性的6.38%(P>0.05)。BMI正常组、超重组及肥胖组的PAD患病率分别为6.67%、6.83%和12.62%,肥胖组PAD的患病率显著高于BMI正常组以及超重组(均P<0.05)。在校正了多个混杂因素后,多元Logistic回归分析显示:BMI是PAD患病的影响因素。②与BMI正常组相比,肥胖组PAD患病风险增加了92%[比值比(OR)=1.92,95%可信区间(CI):1.32～2.75;P=0.000 5]。结论:上海嘉定社区人群中PAD患病率已达7.10%。并且,肥胖是PAD的一个独立危险因素。
Objective: To analyze the prevalence of peripheral arterial disease (PAD) and its relationship with body mass index (BMI) in Shanghai Jiading community population. Methods: A cluster sampling method was used to select 5 435 community residents over the age of 40 in Jiading District, Shanghai. All subjects were tested for oral 75 g glucose tolerance test (OGTT), lipids and ankle brachial index (ABI). ABI <0.9 as a diagnostic criteria for PAD. Logistic regression analysis of BMI and PAD correlation. Results: Among 5 435 subjects, the prevalence of PAD was 7.10%, of which 8.35% for males and 6.38% for females (P> 0.05). The prevalence of PAD in normal BMI group, overweight group and obesity group were 6.67%, 6.83% and 12.62% respectively. The prevalence of PAD in obesity group was significantly higher than that in normal BMI group and overweight group (all P <0.05). After adjusting for multiple confounding factors, multiple logistic regression analysis showed that BMI was the influencing factor of PAD. ② Compared with the normal BMI group, the risk of PAD in obesity group increased by 92% [odds ratio (OR) = 1.92, 95% confidence interval (CI): 1.32-2.75; P = 0.0005]. Conclusion: The prevalence of PAD in Shanghai Jiading community has reached 7.10%. And, obesity is an independent risk factor for PAD.