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目的:针对确诊的声带突肉芽肿,进行质子泵抑制剂(PPI)联合胃动力药物治疗与支撑喉镜下肉毒素注射治疗的对照研究,分析比较2种方法治疗声带突肉芽肿的有效性,以及对患者咽喉部症状和体征的缓解情况。方法:选取2014-12-2016-06期间就诊并符合纳入条件的38例声带突肉芽肿患者,根据患者的治疗意愿分为PPI联合胃动力药物组(28例,其中10例为肉毒素注射失败患者)及肉毒素注射治疗组(20例)。用症状指数量表及体征评分量评估患者治疗前后的症状及体征。结果:2组患者的年龄、性别、病程之间差异无统计学意义。PPI联合胃动力药物治疗的总有效率为96.43%;肉毒素注射组总有效率为45.00%。治疗前2组患者反流症状指数量表及咽喉反流体征量表评分差异无统计学意义;肉芽肿完全消失、复发时,2组患者反流症状指数量表及咽喉反流体征量表评分之间差异有统计学意义。结论:PPI联合胃动力药物治疗声带突肉芽肿的有效率及患者咽喉部症状和体征缓解率较肉毒素注射明显要高。
OBJECTIVE: To compare the efficacy of two kinds of methods in the treatment of patients with vocal cord granuloma by comparing proton pump inhibitor (PPI) with gastric motility drug therapy and botulinum toxin injection with support laryngoscope. As well as the patient’s symptoms and signs of throat relief. METHODS: Thirty-eight patients with condylomata- sylphonucleosis who were treated during the period of 2014-12-2016-06 and eligible for inclusion were enrolled in this study. Patients were divided into PPI combined with gastric motility drug group (28 patients, 10 patients were botulinum toxin injection failure Patients) and botulinum toxin injection treatment group (20 cases). The symptoms and signs of patients before and after treatment were evaluated with the symptom index scale and the scoring system. Results: There was no significant difference in age, sex and course of disease among the two groups. The total effective rate of PPI combined with gastric motility drug treatment was 96.43%; the total effective rate of botulinum toxin injection group was 45.00%. There was no significant difference between the two groups before treatment for reflux symptom index scale and pharyngolaryngeal reflux symptom score scale; granuloma completely disappeared, recurrence, two groups of patients with reflux symptom index scale and pharyngeal reflux syndrome score The difference was statistically significant. Conclusions: The efficacy of PPI combined with gastric motility therapy for treatment of vocal cord granuloma and the improvement of symptom and symptom of throat in patients with polyp toxin were significantly higher than those of botulinum toxin injection.