以家免试验测定热原是国内,外药典规定的传统方法。在长期使用中证实其检测结果与临床应用基本一致。但其方法繁琐,同时有些制剂因生理原因需稀释后方能测定,因而使其灵敏度有所下降;还有部分药品有降温作用影响结果的判断。近年来,国外已广泛将鲎试验(Limulus Test)用于注射药剂及放射性药物的热原检查;国内也有部分单位对此项工作进行探索。我们将1978年11月～ Test-free pyrogen test at home is the traditional method stipulated in Pharmacopoeia at home and abroad. In the long-term use confirmed its test results and clinical application of the same. However, its method is cumbersome, while some preparations due to physiological reasons to be diluted before being measured, resulting in decreased sensitivity; there are some drugs have a cooling effect to determine the outcome. In recent years, Limulus Test has been widely used abroad for the pyrogen test of injectable medicaments and radiopharmaceuticals. Some units in China have also explored this work. We will be November 1978 ~